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Zinc Gluconate vs. Zinc Glycinate — What's the Difference?

By Tayyaba Rehman — Published on November 16, 2023
Zinc gluconate and zinc glycinate are both forms of the mineral zinc, chelated with gluconic acid and glycine, respectively, for enhanced absorption.
Zinc Gluconate vs. Zinc Glycinate — What's the Difference?

Difference Between Zinc Gluconate and Zinc Glycinate


Key Differences

Zinc gluconate is a zinc salt of gluconic acid, commonly used in various pharmaceutical and nutraceutical products. On the other hand, zinc glycinate is the zinc salt of glycine, often selected for its higher bioavailability.
Zinc gluconate is widely recognized for its moderate bioavailability and is often used in over-the-counter (OTC) cold remedies. Meanwhile, zinc glycinate is frequently chosen for nutritional supplements due to its minimal impact on the stomach and optimal absorption.
Zinc gluconate finds its application in various health supplements and is known for being gentle on the digestive system. Contrastingly, zinc glycinate, while also found in supplements, is particularly noted for its ability to be absorbed in the body at a higher rate.
Lastly, both zinc gluconate and zinc glycinate are considered safe and effective forms of zinc supplementation, each providing unique benefits and having specific use cases depending on the intended formulation and purpose.

Comparison Chart

Bonding Acid

Bonded with Gluconic acid.
Bonded with Glycine.


Moderate bioavailability.
High bioavailability.

Digestive Impact

Generally mild on digestion.
Very gentle on the digestive system.

Common Use

Often used in cold remedies.
Common in nutritional supplements.


Typically less expensive.
May be more expensive.

Compare with Definitions

Zinc Gluconate

It is a zinc salt of gluconic acid.
Zinc gluconate is often included in health products.

Zinc Glycinate

It's known for high bioavailability.
Zinc glycinate is often chosen by individuals seeking optimal absorption.

Zinc Gluconate

Zinc gluconate is known for moderate bioavailability.
Some choose zinc gluconate to support immune function.

Zinc Glycinate

It is commonly utilized in nutritional supplements.
My multivitamin contains zinc glycinate for improved uptake.

Zinc Gluconate

Zinc gluconate is recognized for its mild digestive impact.
Zinc gluconate is selected for its tolerability in the stomach.

Zinc Glycinate

Zinc glycinate often carries a higher cost.
I invest in zinc glycinate because of its benefits, despite the price.

Zinc Gluconate

Zinc gluconate is a popular zinc supplement.
Many prefer zinc gluconate for its affordability.

Zinc Glycinate

Zinc glycinate is a zinc chelated with glycine.
I take zinc glycinate for efficient absorption.

Zinc Gluconate

It's widely used in cold remedy products.
I bought zinc gluconate lozenges to soothe my throat.

Zinc Glycinate

Zinc glycinate is gentle on the digestive system.
My doctor recommended zinc glycinate to avoid stomach upset.

Common Curiosities

Can zinc gluconate be used in cold remedies?

Yes, it's common in them.

Which has higher bioavailability: zinc gluconate or zinc glycinate?

Zinc glycinate.

Is zinc glycinate gentle on the stomach?

Yes, it is.

Is zinc glycinate a good choice for optimal absorption?

Yes, it is.

Is zinc glycinate derived from glycine?

Yes, it is.

What are the uses of zinc gluconate?

Nutritional supplements and cold remedies.

Can zinc gluconate support immune function?

Yes, it can.

What is zinc gluconate derived from?

Gluconic acid.

Can zinc glycinate be expensive?

Sometimes, yes.

Does zinc gluconate absorb well in the body?

Moderately well.

Why choose zinc glycinate in supplements?

For its high bioavailability.

What are the general benefits of zinc glycinate?

Enhanced absorption and digestive ease.

Where is zinc glycinate commonly found?

In nutritional supplements.

Is zinc gluconate affordable?

Generally, yes.

Is zinc gluconate safe for consumption?

Yes, it's considered safe.

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Author Spotlight

Written by
Tayyaba Rehman
Tayyaba Rehman is a distinguished writer, currently serving as a primary contributor to As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.

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