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Gout vs. Pseudogout — What's the Difference?

By Tayyaba Rehman — Updated on September 22, 2023
Gout results from uric acid crystals in joints, causing pain; Pseudogout arises from calcium pyrophosphate crystals with similar symptoms.
Gout vs. Pseudogout — What's the Difference?

Difference Between Gout and Pseudogout

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Key Differences

Gout and Pseudogout, while sounding similar, have different causes. Gout is a type of arthritis resulting from the deposition of uric acid crystals within joints. In contrast, Pseudogout is caused by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals. Both conditions lead to painful joint inflammation.
Tayyaba Rehman
Sep 22, 2023
The symptoms of Gout and Pseudogout can be similar, often causing confusion. Gout typically affects the big toe, but can influence other joints too. Pseudogout, on the other hand, often targets the knee, wrist, or other larger joints. Both conditions manifest with sudden, severe pain, redness, warmth, and swelling in the affected joint.
Tayyaba Rehman
Sep 22, 2023
While Gout is primarily linked to elevated levels of uric acid in the blood, several factors contribute to its onset, including genetics, diet, and kidney function. Pseudogout, conversely, doesn't have as clear a link to specific triggers, though age, genetics, and mineral imbalances may play roles.
Tayyaba Rehman
Sep 22, 2023
Treatment for Gout primarily focuses on managing pain and reducing uric acid levels, employing medications like NSAIDs, corticosteroids, and drugs that alter uric acid production or excretion. Pseudogout treatments also involve pain management with anti-inflammatory drugs, but there's no specific treatment to dissolve CPPD crystals or prevent their formation.
Tayyaba Rehman
Sep 22, 2023
Lastly, while both conditions can cause joint damage over time, their management and prognoses can vary. Proper diagnosis is essential since Gout and Pseudogout require different approaches to treatment and prevention.
Tayyaba Rehman
Sep 22, 2023
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Comparison Chart

Causative Crystal

Uric acid crystals
Calcium pyrophosphate dihydrate crystals
Tayyaba Rehman
Sep 22, 2023

Commonly Affected Joints

Big toe, can affect other joints
Knees, wrists, and larger joints
Tayyaba Rehman
Sep 22, 2023

Primary Causes

Elevated uric acid, genetics, diet, kidney function
Age, genetics, mineral imbalances
Tayyaba Rehman
Sep 22, 2023

Treatment

NSAIDs, corticosteroids, uric acid-altering drugs
Anti-inflammatory drugs, no specific treatments for crystals
Tayyaba Rehman
Sep 22, 2023

Symptoms Onset

Can be sudden and severe
Often sudden with severe pain
Tayyaba Rehman
Sep 22, 2023

Compare with Definitions

Gout

Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint. Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours.
Tayyaba Rehman
Dec 06, 2022

Pseudogout

A type of arthritis caused by calcium pyrophosphate crystal deposition.
The severe knee pain was a symptom of Pseudogout.
Tayyaba Rehman
Sep 22, 2023

Gout

A disturbance of uric-acid metabolism occurring chiefly in males, characterized by painful inflammation of the joints, especially of the feet and hands, and arthritic attacks resulting from elevated levels of uric acid in the blood and the deposition of urate crystals around the joints. The condition can become chronic and result in deformity.
Tayyaba Rehman
Dec 06, 2022

Pseudogout

A medical disorder linked to age, genetics, and mineral imbalances.
As she aged, she became more susceptible to Pseudogout.
Tayyaba Rehman
Sep 22, 2023

Gout

A large blob or clot
"and makes it bleed great gouts of blood" (Oscar Wilde).
Tayyaba Rehman
Dec 06, 2022

Pseudogout

A joint condition resembling Gout but with different causative crystals.
Pseudogout and Gout can often be mistaken due to their similar symptoms.
Tayyaba Rehman
Sep 22, 2023

Gout

An extremely painful inflammation of joints, especially of the big toe, caused by a metabolic defect resulting in the accumulation of uric acid in the blood and the deposition of urates around the joints.
Tayyaba Rehman
Dec 06, 2022

Pseudogout

An inflammatory ailment targeting larger joints.
Her wrist inflammation was identified as Pseudogout.
Tayyaba Rehman
Sep 22, 2023

Gout

A spurt or splotch.
Tayyaba Rehman
Dec 06, 2022

Pseudogout

A condition resulting in sudden, painful joint flare-ups.
He was advised rest during his Pseudogout attack.
Tayyaba Rehman
Sep 22, 2023

Gout

(rare) A disease of wheat and cornstalks, caused by insect larvae.
Tayyaba Rehman
Dec 06, 2022

Pseudogout

(medicine) A medical condition with symptoms resembling gout but caused by precipitation of calcium pyrophosphate crystals in the joints instead of monosodium urate crystals.
Tayyaba Rehman
Dec 06, 2022

Gout

(obsolete) taste; relish
Tayyaba Rehman
Dec 06, 2022

Gout

(intransitive) To spurt.
Tayyaba Rehman
Dec 06, 2022

Gout

A drop; a clot or coagulation.
On thy blade and dudgeon gouts of blood.
Tayyaba Rehman
Dec 06, 2022

Gout

A constitutional disease, occurring by paroxysms. It consists in an inflammation of the fibrous and ligamentous parts of the joints, and almost always attacks first the great toe, next the smaller joints, after which it may attack the greater articulations. It is attended with various sympathetic phenomena, particularly in the digestive organs. It may also attack internal organs, as the stomach, the intestines, etc. It is an inherited disease of purine metaboism, which causes an increased level of uric acid in the blood, and leads to deposition of crystals of sodium urate in cartilage within joints and in connective tissue. It can be alleviated by a diet low in purines, and is treated by drugs which block formation of uric acid.
Tayyaba Rehman
Dec 06, 2022

Gout

A disease of cornstalks. See Corn fly, under Corn.
Tayyaba Rehman
Dec 06, 2022

Gout

Taste; relish.
Tayyaba Rehman
Dec 06, 2022

Gout

A painful inflammation of the big toe and foot caused by defects in uric acid metabolism resulting in deposits of the acid and its salts in the blood and joints
Tayyaba Rehman
Dec 06, 2022

Common Curiosities

What causes Gout?

Gout is caused by the buildup of uric acid crystals in the joints.
Tayyaba Rehman
Sep 22, 2023

Which joints are commonly affected by Gout?

Gout commonly affects the big toe but can impact other joints as well.
Tayyaba Rehman
Sep 22, 2023

What is a common joint affected by Pseudogout?

Pseudogout frequently affects the knees, wrists, and larger joints.
Tayyaba Rehman
Sep 22, 2023

Can diet influence Gout?

Yes, a diet high in purines, like red meat, can raise uric acid levels, contributing to Gout.
Tayyaba Rehman
Sep 22, 2023

How is Pseudogout different from Gout?

Pseudogout is caused by calcium pyrophosphate crystals, while Gout is due to uric acid crystals.
Tayyaba Rehman
Sep 22, 2023

Is there a cure for Pseudogout?

No, there's no cure, but symptoms can be managed with anti-inflammatory drugs.
Tayyaba Rehman
Sep 22, 2023

How is Gout treated?

Gout treatment includes NSAIDs, corticosteroids, and drugs that manage uric acid levels.
Tayyaba Rehman
Sep 22, 2023

Can Gout lead to other health complications?

Yes, untreated Gout can cause joint damage and kidney stones.
Tayyaba Rehman
Sep 22, 2023

Can Gout be prevented?

Gout flare-ups can be reduced or prevented with medication, diet, and lifestyle changes.
Tayyaba Rehman
Sep 22, 2023

What triggers a Pseudogout flare-up?

Triggers can include trauma, surgery, or underlying health conditions.
Tayyaba Rehman
Sep 22, 2023

How is Pseudogout diagnosed?

It's diagnosed through joint fluid analysis, X-rays, and other tests.
Tayyaba Rehman
Sep 22, 2023

Are older individuals more at risk for Pseudogout?

Yes, Pseudogout risk increases with age.
Tayyaba Rehman
Sep 22, 2023

Why is it called "Pseudogout"?

It's named so because it mimics Gout symptoms but has a different cause.
Tayyaba Rehman
Sep 22, 2023

Are Gout and Pseudogout hereditary?

Both conditions can have a genetic component, increasing susceptibility.
Tayyaba Rehman
Sep 22, 2023

Is Gout more common in men or women?

Gout is more common in men, but the risk for women increases after menopause.
Tayyaba Rehman
Sep 22, 2023

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Author Spotlight

Written by
Tayyaba Rehman
Tayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.

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