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Adequan vs. Legend — What's the Difference?

By Fiza Rafique & Urooj Arif — Published on April 8, 2024
Adequan, an injectable disease-modifying osteoarthritis drug, is used to treat joint dysfunction, while Legend, an intravenous solution, targets inflammation in joints to alleviate symptoms of osteoarthritis.
Adequan vs. Legend — What's the Difference?

Difference Between Adequan and Legend


Key Differences

Adequan is primarily known for its ability to stimulate cartilage repair and reverse joint damage, making it a disease-modifying osteoarthritis drug (DMOAD). It is administered through intramuscular injections directly targeting affected joints. On the other hand, Legend works as an anti-inflammatory agent, reducing the symptoms of osteoarthritis by inhibiting inflammatory processes. It is given intravenously, offering a systemic approach to managing joint pain and inflammation.
Adequan's active ingredient, polysulfated glycosaminoglycan, is designed to enhance the production of joint lubricating fluids and support the repair of damaged cartilage. This makes it particularly effective in the early stages of osteoarthritis. Whereas, Legend's active component, hyaluronate sodium, works by improving the quality of the synovial fluid, thereby reducing friction and enhancing joint function, making it beneficial at various stages of joint issues.
The treatment regimen for Adequan typically involves a series of injections over a specific period, which can provide long-term benefits to the joint structure and function. Conversely, Legend may require less frequent administration, focusing on immediate relief from acute inflammation and pain, which can be particularly useful during flare-ups of osteoarthritis.
Adequan is often recommended for horses with more advanced joint degradation or for those where there is a clear need for cartilage repair and regeneration. In contrast, Legend is usually preferred for managing acute episodes of joint pain and swelling, making it a go-to for immediate relief rather than long-term joint health.
While Adequan's effects are localized to the joints treated and can lead to visible improvements in joint health over time, Legend's systemic approach means it can address inflammation throughout the body, providing broad relief from osteoarthritis symptoms without specifically targeting joint repair.

Comparison Chart


Disease-modifying osteoarthritis drug (DMOAD)
Anti-inflammatory agent


Intramuscular injection
Intravenous injection

Primary Action

Stimulates cartilage repair and joint lubrication
Reduces joint inflammation and improves fluid quality

Treatment Regimen

Series of injections over weeks
Single or less frequent doses

Ideal Use

Early-stage osteoarthritis, long-term joint health
Acute inflammation, immediate relief

Compare with Definitions


An injectable solution containing polysulfated glycosaminoglycan.
Adequan injections are administered directly into the muscle to ensure the drug reaches the affected joints.


Contains hyaluronate sodium to improve synovial fluid quality.
Legend works by enhancing the synovial fluid, reducing joint friction.


A medication used to treat joint dysfunction in horses.
The veterinarian recommended starting Adequan injections to help with my horse's arthritis.


An intravenous solution used for treating joint inflammation in horses.
The vet administered Legend to quickly address my horse's joint swelling.


A treatment option that supports cartilage repair and enhances joint lubrication.
After a few weeks of Adequan treatment, the horse showed improved mobility.


Offers rapid relief from symptoms of osteoarthritis.
After the Legend injection, there was noticeable improvement in the horse's gait within hours.


Administered through a series of intramuscular injections.
The treatment plan involves Adequan injections twice a week for four weeks.


Typically used for acute flare-ups of osteoarthritis.
During an osteoarthritis flare-up, Legend can provide immediate symptom relief.


A DMOAD used to modify the disease process of osteoarthritis.
Adequan is unique because it not only treats symptoms but also helps reverse joint damage.


Given intravenously, allowing for quick systemic action.
The systemic action of Legend means it can quickly reach joints throughout the body.

Common Curiosities

What is Adequan used for?

Adequan is used to treat joint dysfunction in horses by stimulating cartilage repair and enhancing joint lubrication.

How often are Adequan injections given?

Adequan injections are typically given in a series, often starting with twice a week for up to 4 weeks, depending on the veterinarian's recommendation.

Can Adequan reverse joint damage?

Yes, Adequan can help reverse joint damage by promoting cartilage repair and enhancing joint fluid production.

Is there a risk of side effects with Adequan?

Like any medication, Adequan can have side effects, but it is generally considered safe when administered according to veterinary guidelines.

Can Adequan be used for horses at any stage of osteoarthritis?

Adequan is most effective in the early stages of osteoarthritis but can be beneficial at various stages depending on the severity of joint degradation.

What is the main component of Legend?

The main component of Legend is hyaluronate sodium, which improves the quality of synovial fluid in the joints.

What makes Legend different from other anti-inflammatory drugs?

Legend specifically targets joint inflammation by improving synovial fluid quality, making it uniquely effective for joint issues.

How is Legend administered?

Legend is administered through intravenous injection, providing systemic relief from joint inflammation.

Is Legend effective for long-term joint health?

Legend is primarily used for immediate relief from inflammation and is not specifically aimed at long-term joint health.

Is Legend a long-term solution for osteoarthritis?

Legend provides immediate relief but is not necessarily a long-term solution for managing osteoarthritis.

Can Legend be used in conjunction with other treatments?

Legend can be used alongside other treatments, but it's essential to consult with a veterinarian for a comprehensive treatment plan.

How quickly does Legend work?

Legend can provide relief from joint inflammation and pain within hours of administration.

Can Adequan improve overall mobility in horses?

Yes, by repairing cartilage and improving joint function, Adequan can enhance overall mobility in horses.

What are the key differences between Adequan and Legend?

Adequan is a DMOAD that helps repair joint cartilage and is administered intramuscularly, while Legend is an anti-inflammatory agent that improves synovial fluid quality and is given intravenously for quick relief.

Does Adequan need to be administered directly into the joint?

No, Adequan is administered via intramuscular injections, not directly into the joint.

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Author Spotlight

Written by
Fiza Rafique
Fiza Rafique is a skilled content writer at, where she meticulously refines and enhances written pieces. Drawing from her vast editorial expertise, Fiza ensures clarity, accuracy, and precision in every article. Passionate about language, she continually seeks to elevate the quality of content for readers worldwide.
Co-written by
Urooj Arif
Urooj is a skilled content writer at Ask Difference, known for her exceptional ability to simplify complex topics into engaging and informative content. With a passion for research and a flair for clear, concise writing, she consistently delivers articles that resonate with our diverse audience.

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