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Synthesise vs. Synthesize — What's the Difference?

Edited by Tayyaba Rehman — By Urooj Arif — Updated on February 29, 2024
"Synthesise" and "synthesize" are two spellings of the same verb, meaning to combine elements to form a coherent whole, with "synthesise" being the British English spelling and "synthesize" the American English spelling.
Synthesise vs. Synthesize — What's the Difference?

Difference Between Synthesise and Synthesize

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Key Differences

The verb "to synthesize" refers to the process of combining different elements or components to form a new, unified entity. This term is widely used in various fields, such as chemistry, music, and writing. In chemistry, it refers to the process of creating chemical compounds by reaction from simpler materials. In music, synthesizing involves creating sounds or music by blending different sound waves or samples. In writing, it means combining ideas from various sources into a cohesive argument or narrative.
The difference in spelling—"synthesise" in British English and "synthesize" in American English—reflects the broader pattern of spelling variations between these two versions of English. Other examples include "realise" vs. "realize" and "analyse" vs. "analyze." These variations do not impact the meaning of the words; they simply reflect regional spelling preferences.
Despite the spelling differences, the pronunciation of "synthesise" and "synthesize" remains largely the same, with minor variations in accent or emphasis according to regional dialects. This uniformity in pronunciation ensures that the word is recognized and understood in both written and spoken forms across English-speaking regions.
The choice between "synthesise" and "synthesize" depends on the intended audience or the standard writing conventions of the region. For instance, British publications and institutions might favor "synthesise," while American ones typically use "synthesize." Writers and speakers are encouraged to be consistent with their choice of spelling to maintain coherence in their communication.
Understanding these spelling variations is crucial for effective communication in English, especially in academic and professional contexts where precision and adherence to language conventions are valued. It also highlights the richness and diversity of English, accommodating regional expressions while maintaining a shared understanding.
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Comparison Chart

Spelling

Synthesise
Synthesize

Usage

Preferred in British, Australian, and other Commonwealth English
Preferred in American English

Fields of Use

Chemistry, music, writing, etc.
Chemistry, music, writing, etc.

Meaning

To combine elements to form a coherent whole
To combine elements to form a coherent whole

Pronunciation

Largely the same, with regional variations
Largely the same, with regional variations

Compare with Definitions

Synthesise

To combine disparate ideas into a coherent whole.
The thesis synthesises theories from psychology and economics.

Synthesize

To form a substance chemically from simpler substances.
Scientists synthesize new drugs to treat rare diseases.

Synthesise

To produce sound electronically.
The musician used a synthesiser to synthesise unique sounds for the track.

Synthesize

To amalgamate various research findings into a summary.
The paper synthesizes decades of research on renewable energy.

Synthesise

To create a chemical compound by reaction from simpler materials.
The lab aims to synthesise a new form of biodegradable plastic.

Synthesize

To create music using electronic instruments.
She loves to synthesize music using her laptop and keyboard.

Synthesise

To construct something digitally or artificially.
The team synthesised realistic environmental conditions for the simulation.

Synthesize

To integrate different pieces of information into a new whole.
The author synthesized historical facts and fiction in her novel.

Synthesise

To compile data or information cohesively.
The report synthesises findings from various studies on climate change.

Synthesize

To produce or fabricate by combining parts artificially.
The company synthesizes diamond-like materials for industrial use.

Synthesise

Standard spelling of synthesize

Synthesize

Make (something) by synthesis, especially chemically
The drug was first synthesized in 1929

Synthesise

Combine so as to form a more complex, product;
His operas synthesize music and drama in perfect harmony

Synthesize

To form or produce by chemical synthesis.

Synthesize

To form a synthesis.

Synthesize

To produce a substance by chemical synthesis.

Synthesize

To be produced by chemical synthesis.

Synthesize

To combine by synthesis; to unite.

Synthesize

Combine so as to form a more complex, product;
His operas synthesize music and drama in perfect harmony

Synthesize

Combine and form a synthesis

Common Curiosities

Can "synthesise" and "synthesize" be used interchangeably?

While they can be understood interchangeably, the choice of spelling should match the regional convention of the audience or publication.

How should I decide whether to use "synthesise" or "synthesize"?

Consider your audience or the standard language practices of the region where your writing will be published or presented.

Is there a difference in meaning between "synthesise" and "synthesize"?

No, there is no difference in meaning; the variation is purely in spelling according to British and American English conventions.

Does the spelling variation affect pronunciation?

Pronunciation remains largely the same for both spellings, with only slight regional differences in accent or emphasis.

How has the use of "synthesise" vs. "synthesize" evolved?

The use reflects broader trends in English spelling standardization, with variations persisting due to historical and cultural differences between British and American English.

Is one spelling more correct than the other?

No, both spellings are correct within their respective regional conventions of English.

Are there other words with similar British and American spelling variations?

Yes, there are many, including "organise" vs. "organize" and "colour" vs. "color."

In scientific writing, which spelling is preferred?

The preference depends on the journal or institution's guidelines, with American journals typically using "synthesize" and British or Commonwealth journals favoring "synthesise."

Is it important to be consistent in using either British or American spelling in a document?

Yes, consistency in spelling within a document is important for professionalism and readability, especially in formal or academic writing.

Can software detect and correct the use of "synthesise" vs. "synthesize"?

Yes, most spell-checking software can be set to either British or American English standards and will suggest corrections accordingly.

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Author Spotlight

Written by
Urooj Arif
Urooj is a skilled content writer at Ask Difference, known for her exceptional ability to simplify complex topics into engaging and informative content. With a passion for research and a flair for clear, concise writing, she consistently delivers articles that resonate with our diverse audience.
Tayyaba Rehman is a distinguished writer, currently serving as a primary contributor to askdifference.com. As a researcher in semantics and etymology, Tayyaba's passion for the complexity of languages and their distinctions has found a perfect home on the platform. Tayyaba delves into the intricacies of language, distinguishing between commonly confused words and phrases, thereby providing clarity for readers worldwide.

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