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Diazepam vs. Zopiclone — What's the Difference?

By Maham Liaqat & Fiza Rafique — Updated on March 10, 2024
Diazepam is a sedative medication used for anxiety and seizures, whereas Zopiclone aids sleep.
Diazepam vs. Zopiclone — What's the Difference?

Difference Between Diazepam and Zopiclone

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Key Differences

Diazepam, a benzodiazepine, is widely recognized for its calming effects and is commonly prescribed for anxiety, muscle spasms, and seizures. It enhances the activity of neurotransmitters in the brain to induce sedation and relaxation. Whereas Zopiclone, a non-benzodiazepine hypnotic agent, is specifically designed to combat insomnia by facilitating the onset of sleep and maintaining uninterrupted sleep patterns.
Diazepam has a longer duration of action, making it suitable for conditions requiring sustained relief, whereas Zopiclone's effects are more short-lived, tailored for overnight sleep without residual drowsiness. Diazepam's versatile applications also include alcohol withdrawal therapy and as a premedication for anxiety-inducing procedures, highlighting its broad therapeutic scope.
In terms of dependency and withdrawal, Diazepam, due to its longer half-life and broader usage, may lead to more pronounced dependency issues and a more complex withdrawal process. Zopiclone, while also carrying a risk of dependence, especially with long-term use, generally has a lesser propensity for tolerance and withdrawal symptoms.
The side effect profiles of both medications also differ; Diazepam may cause drowsiness, muscle weakness, and impaired coordination. Zopiclone, on the other hand, is known for its potential to cause a metallic taste, morning grogginess, and less commonly, sleepwalking or other complex sleep-related behaviors.

Comparison Chart

Primary Use

Anxiety, seizures, muscle spasms
Insomnia
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Drug Class

Benzodiazepine
Non-benzodiazepine hypnotic

Duration of Action

Long
Short

Risk of Dependency

Higher
Lower

Common Side Effects

Drowsiness, muscle weakness
Metallic taste, morning grogginess

Compare with Definitions

Diazepam

It eases muscle spasms.
Diazepam was given post-surgery to relax his muscles.

Zopiclone

Zopiclone induces sleep.
She takes zopiclone to overcome her insomnia.

Diazepam

Diazepam relieves anxiety.
The doctor prescribed diazepam to help with her panic attacks.

Zopiclone

Reduces time to fall asleep.
Zopiclone helped him fall asleep faster.

Diazepam

It helps control seizures.
Diazepam is part of his treatment plan for epilepsy.

Zopiclone

Used for brief periods.
The doctor recommended zopiclone for two weeks only.

Diazepam

It induces calmness and sedation.
Diazepam was administered before the dental procedure for sedation.

Zopiclone

Prevents night awakenings.
With zopiclone, she didn't wake up in the middle of the night.

Diazepam

Assists in alcohol withdrawal.
Diazepam helped him manage the symptoms of alcohol withdrawal.

Zopiclone

A different class from traditional sedatives.
He was prescribed zopiclone, a non-benzodiazepine, for his sleep issues.

Diazepam

Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome.

Zopiclone

Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone.

Diazepam

A benzodiazepine drug, C16H13ClN2O, used to treat anxiety and alcohol withdrawal and as a sedative, skeletal muscle relaxant, and anticonvulsant.

Zopiclone

A nonbenzodiazepine sedative used to treat insomnia.

Diazepam

(pharmaceutical drug) A tranquilizing muscle relaxant drug (trademark Valium) used chiefly to relieve anxiety.

Diazepam

A tranquilizer (trade name Valium) used to relieve anxiety and relax muscles; acts by enhancing the inhibitory actions of the neurotransmitter GABA; can also be used as an anticonvulsant drug in cases of nerve agent poisoning

Common Curiosities

How does Zopiclone work?

Zopiclone works by inducing sleep and is used primarily to treat insomnia.

What are the common side effects of Diazepam?

Common side effects include drowsiness, muscle weakness, and impaired coordination.

What is Diazepam used for?

Diazepam is used to treat anxiety, muscle spasms, seizures, and alcohol withdrawal symptoms.

How quickly does Zopiclone take effect?

Zopiclone typically takes effect within 1 hour, facilitating sleep onset.

Is Diazepam effective for anxiety?

Yes, Diazepam is highly effective in managing anxiety symptoms.

Is Zopiclone safe for long-term use?

Zopiclone is generally prescribed for short-term use due to the risk of dependency and tolerance.

Can Zopiclone cause a metallic taste?

Yes, a metallic taste is a common side effect of Zopiclone.

Can Diazepam cause dependency?

Yes, Diazepam can lead to physical and psychological dependency, especially with long-term use.

Are there any dietary restrictions with Zopiclone?

It's advised to avoid alcohol and reduce caffeine intake while taking Zopiclone.

Can Zopiclone lead to next-day drowsiness?

Zopiclone can cause morning grogginess, especially if not enough sleep time is allowed.

What should I do if I miss a dose of Zopiclone?

If a dose is missed, it should be taken as soon as remembered, or skipped if it's almost time for the next dose.

Can Diazepam be used for sleep?

While Diazepam can induce sedation, it's not primarily prescribed for sleep due to its long duration of action.

Is it possible to develop tolerance to Diazepam?

Yes, tolerance to Diazepam can develop, necessitating higher doses for the same effect.

Can Diazepam and Zopiclone be taken together?

Combining Diazepam and Zopiclone is generally not recommended due to increased sedation and risk of side effects.

How should Diazepam be discontinued?

Diazepam should be tapered off gradually under medical supervision to avoid withdrawal symptoms.

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Author Spotlight

Written by
Maham Liaqat
Co-written by
Fiza Rafique
Fiza Rafique is a skilled content writer at AskDifference.com, where she meticulously refines and enhances written pieces. Drawing from her vast editorial expertise, Fiza ensures clarity, accuracy, and precision in every article. Passionate about language, she continually seeks to elevate the quality of content for readers worldwide.

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